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KMID : 1140120110160030249
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Cancer Prevention Research
2011 Volume.16 No. 3 p.249 ~ p.254
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The Protective Effects of Common and Tartary Buckwheats against Oxidative Stress and Gastric Cancer
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Lee Hae-Song
Lee Jeong-Min
Yoon Young-Ho
Cho Eun-Ju
Lee Sang-Hyun
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Abstract
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The protective effects of tartary buckwheat and common Korean buckwheat cultivars, yangjul-maemil and daesan-maemil, against oxidative stress and gastric cancer were evaluated. The treatment of the methanol extract from tartary buckwheat, yangjul-maemil and daesan-maemil showed over 80% scavenging effect against 1,1-diphenyl-2-picrylhydrazyl at 250 μg/ml. In addition, all buckwheats showed over 80% ㆍOH scavenging activity even at low concentration of 50 μg/ml. In order to investigate the anti-inflammatory activity of tartary buckwheat, yangjul-maemil and daesan-maemil, we employed nitric oxide (NO) induced cellular inflammatory system using RAW 264.7 macrophage cells. The results showed that tartary buckwheat, yangjul-maemil and daesan-maemil inhibited NO production generated by both exotoxin of sodium nitroprusside and endotoxin of lipopolysaccharide & interferon-gamma. Morever, tartary buckwheat and daesan-maemil showed the strong antimicrobial activity (clear zone ＞14 mm) against Helicobacter pylori. Yangjul-maemil and daesan-maemil also inhibited the growth of AGS human gastric adenocarcinoma cells by up to 70% at concentration of 1,000 μg/ml. The present results indicate that buckwheats showed protective effects against oxidative stress and gastric cancer.
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KEYWORD
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Tartary buckwheat (Fagopyrum tataricum), Yangjul-maemil, Daesan-maemil, Oxidative stress, Helicobacter pylori, AGS human gastric adenocarcinoma cell
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